Parameter
| Biomarker | BCAT1 | Full name | Branched-Chain Amino Acid Transaminase 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis, therapeutic targets | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Bone marrow (RNA sequencing, qRT-PCR) | ||
| Pathobiological Mechanisms | Promoting the development of AML through the FLT3-ITD/BCAT1/MYC pathway | ||||
| Clinical Availability Status | Research validation: High expression in the NPM1+FLT3-ITD+ subtype. | ||||
| Notes and Dynamics | The predictive prognostic ability is superior to the FLT3-ITD allele ratio, and FLT3 inhibitors can downregulate its expression. | ||||