Parameter
| Biomarker | STMN1 | Full name | Stathmin 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis, therapeutic targets | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Peripheral blood mononuclear cells/bone marrow (RT-PCR, Western blot, flow cytometry) | ||
| Pathobiological Mechanisms | Activates the PI3K/Akt pathway, promotes cell proliferation, and inhibits apoptosis, resulting in G1 phase arrest | ||||
| Clinical Availability Status | Research verification: Expression levels correlate with FAB subtype, risk stratification, and survival duration. | ||||
| Notes and Dynamics | Inhibition of STMN1 upregulates caspase3 and Bax, providing a therapeutic target. | ||||