Parameter
| Biomarker | OPNb/OPNc | Full name | Osteopontin isoform b/isoform c | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis (recurrent-related) | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Bone marrow (real-time quantitative PCR) | ||
| Pathobiological Mechanisms | Persistent overexpression after chemotherapy, associated with the VEGFc/STAT3/CXCR4 pathway, promotes recurrence. | ||||
| Clinical Availability Status | Research validation: Overexpression was more pronounced in the M0, M1, and M2 subgroups. | ||||
| Notes and Dynamics | It can serve as a biomarker for the recurrence of AML, requiring further clinical validation. | ||||