Parameter
| Biomarker | ALOX5AP | Full name | Arachidonate 5-Lipoxygenase Activating Protein | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrowBlood, bone marrow | Test Sample / Technology Platform | Bone marrow (qRT-PCR, DNA methylation sequencing) | ||
| Pathobiological Mechanisms | Hypomethylation leads to overexpression, which is positively correlated with pro-leukemia genes and inhibits tumor-suppressive miRNAs. | ||||
| Clinical Availability Status | Study validation: Four independent cohorts (n=1186) confirm its prognostic value | ||||
| Notes and Dynamics | ROC curve demonstrates AML discrimination capability, with high expression indicating reduced overall survival | ||||