Parameter
| Biomarker | PTBP1 | Full name | Polypyrimidine Tract Binding Protein 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, risk prediction | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Bone marrow (qRT-PCR, Western blot) | ||
| Pathobiological Mechanisms | Associated with internal tandem repeat mutations and complex karyotypes in FLT3, promoting cell proliferation and inhibiting apoptosis | ||||
| Clinical Availability Status | Research validation: The area under the curve (AUC) of 0.8601 can distinguish AML patients from the control group. | ||||
| Notes and Dynamics | Positively correlated with the proliferation marker Ki-67 and negatively correlated with the apoptosis marker p53, representing a potential drug target. | ||||