Parameter
| Biomarker | IL1R1 | Full name | Interleukin 1 Receptor Type 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis and treatment benefit prediction | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Bone marrow (RNA sequencing, qRT-PCR) | ||
| Pathobiological Mechanisms | High expression is associated with monocyte differentiation and FLT3-ITD/RUNX1 mutations, increasing the risk of recurrence. | ||||
| Clinical Availability Status | Study validation: The Leucegene cohort (n=316) confirmed its value. | ||||
| Notes and Dynamics | Hematopoietic stem cell transplantation significantly improves 5-year overall survival in patients with high expression of intermediate-risk AML. | ||||