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165

Parameter
Biomarker Gut microbiota Full name Gut microbiota Molecular Type Microorganism
Molecular Formula / Molecular Weight / Core Functional Dimensions Early diagnosis、Risk assessment
Disease Chronic Kidney Disease (CKD) Disease Subtypes /
Organ Kidney Test Sample / Technology Platform Feces, blood ( metagenomic sequencing, flora analysis )
Pathobiological Mechanisms The progress of CKD leads to the imbalance of intestinal flora, the decrease of probiotics and the increase of pathogenic bacteria, which leads to the damage of intestinal
Clinical Availability Status Research and exploration stage
Notes and Dynamics The metabolites of intestinal flora ( such as indole and phenols ) can be used as uremic toxins to aggravate kidney damage, and related markers are expected to become non-invasive screening tools.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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