Parameter
| Biomarker | TIMP-2×IGFBP7 | Full name | Tissue inhibitor of metalloproteinases-2 × Insulin-like growth factor-binding protein 7 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Early warning, cell cycle arrest monitoring |
| Disease | Acute Kidney Injury (AKI) | Disease Subtypes | / | ||
| Organ | Kidney | Test Sample / Technology Platform | Urine（NephroCheck™/Kits/Bedside testing） | ||
| Pathobiological Mechanisms | The release of renal tubular epithelial cells after stress reflects cell cycle arrest, suggesting the risk of AKI. | ||||
| Clinical Availability Status | FDA approval / Cinical application | ||||
| Notes and Dynamics | The only FDA-approved AKI risk assessment marker that predicts moderate to severe AKI within 12-24 hours has been validated in trauma ICU populations. | ||||