Parameter
| Biomarker | LH/FSH | Full name | Luteinizing hormone/Follicle-stimulating hormone | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis |
| Disease | PCOS | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (CLIA, ELISA) | ||
| Pathobiological Mechanisms | Disorder of the hypothalamus - pituitary - ovary (HPO) axis leads to an increase in the frequency and amplitude of LH pulses, a relative insufficiency in FSH secretion, and an elevated LH/FSH ratio, which inhibits follicle maturation and promotes the synthesis of androgens in the ovary. | ||||
| Clinical Availability Status | Clinical routine auxiliary diagnosis: Classic endocrine indicators, commonly used for differentiating PCOS from other disorders of ovulation. | ||||
| Notes and Dynamics | An adult female with an LH/FSH ratio of ≥ 2.5 often indicates PCOS. However, for adolescent PCOS patients, the significance of this ratio is limited (as the HPO axis in adolescence is not yet stable); using it alone is insufficient in sensitivity, and it is necessary to combine with hyperandrogenism or ovarian morphology indicators. | ||||