Parameter
| Biomarker | AMH1 | Full name | Anti-Müllerian hormone | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Monitoring |
| Disease | PCOS | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (CLIA, ELISA) | ||
| Pathobiological Mechanisms | In patients with PCOS, the number of pre-schisis follicles and small antral follicles in the ovaries significantly increases (manifesting polycystic changes). AMH, which is secreted by the granulosa cells of pre-schisis follicles, is positively correlated with the number of follicles and can reflect the "polycystic" reserve characteristics of the ovaries. | ||||
| Clinical Availability Status | The number of pre-antral follicles and small antral follicles in the ovaries of PCOS patients significantly increased (the common clinical indicators for polycystic changes: widely used for assessing ovarian reserve and diagnosing PCOS). | ||||
| Notes and Dynamics | The level of AMH in PCOS patients is usually 2-3 times that of healthy women, and its sensitivity for diagnosing polycystic ovaries is up to 85%-90%. It should be noted that it needs to be differentiated from premature ovarian failure (where AMH is extremely low), and AMH alone cannot diagnose PCOS. Other criteria must also be combined. | ||||