Parameter
| Biomarker | sCD146 | Full name | Soluble CD146 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | ~85 kDa | Core Functional Dimensions | Diagnosis of congestion and assessment of endothelial function | |
| Disease | Heart failure | Disease Subtypes | / | ||
| Organ | Vascular endothelial cells, smooth muscle cells | Test Sample / Technology Platform | Plasma (ELISA and western blot method) | ||
| Pathobiological Mechanisms | Connexin, which is released in response to endothelial injury caused by venous congestion, specifically reflects systemic venous congestion | ||||
| Clinical Availability Status | Gayat et al. showed that the AUC for diagnosis of acute HF was 0.87 (close to 0.92 for NT-proBNP); positively correlated with IVC diameter (reflecting right heart pressure) (r=0.48) | ||||
| Notes and Dynamics | The NT-proBNP in "grey zone" (300-900 pg/ml), sCD146 can improve diagnostic accuracy (NRI = 0.23); Chronic HF sCD146 > 5 ng/ml tip 6 months 1.7 times increased risk of worsening heart failure; It is not affected by renal function and is suitable for patients with CKD and HF | ||||