Parameter
| Biomarker | TP53 | Full name | Tumor protein p53 | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 53 kDa | Core Functional Dimensions | Diagnosis and prognosis | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | All cells (tumor suppressor) | Test Sample / Technology Platform | Organization (NGS, WES, WGS, PCR-based DNA sequencing) | ||
| Pathobiological Mechanisms | Loss of tumor suppressor gene function lead to genomic instability, promote angiogenesis and tumor cell proliferation | ||||
| Clinical Availability Status | Research/clinical validation: widely exists in various subtypes, head and neck subtype mutation rate is higher | ||||
| Notes and Dynamics | The mutation frequency was 27% (10%-69%), mainly missense mutation, which was associated with the up-regulation of VEGF expression | ||||