Parameter
| Biomarker | POT1 | Full name | Protection of telomeres 1 | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 70 kDa | Core Functional Dimensions | Susceptibility, prognosis | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | All cells (telomere maintenance) | Test Sample / Technology Platform | Tissue (NGS, WES, WGS) | ||
| Pathobiological Mechanisms | Telomere protective proteins function abnormally and promote chromosome instability and tumorigenesis | ||||
| Clinical Availability Status | Study validation: Enriched in head and neck subtypes | ||||
| Notes and Dynamics | The mutation frequency was 17% (16%-19%), and the mutation probability in AS was 11 times higher than that in other tumors. Most of the mutations were missense mutations | ||||