Parameter
| Biomarker | PTPRB | Full name | Protein tyrosine phosphatase receptor type B | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 190 kDa | Core Functional Dimensions | Therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Vascular endothelial cells, tumor cells | Test Sample / Technology Platform | Tissue (NGS, WES, WGS) | ||
| Pathobiological Mechanisms | Loss of tyrosine phosphatase function can relieve the inhibition of ANGPT-TIE2 pathway and enhance angiogenesis | ||||
| Clinical Availability Status | The study verified that the mutations were mainly truncated mutations | ||||
| Notes and Dynamics | The mutation frequency is 18% (11%-29%), which drives tumor progression by activating the PI3K/Akt/mTOR pathway | ||||