Parameter
| Biomarker | KDR (VEGFR2) | Full name | Kinase insert domain receptor (vascular endothelial growth factor receptor 2) | Molecular Type | Nucleic acid (DNA)/protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 150 kDa | Core Functional Dimensions | Diagnostic, therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Vascular endothelial cells, tumor cells | Test Sample / Technology Platform | Tissue (NGS, WES, WGS, IHC, FISH) | ||
| Pathobiological Mechanisms | Gain function mutation or overexpression activates VEGF pathway and promotes endothelial cell proliferation and migration | ||||
| Clinical Availability Status | Clinical validation/therapeutic targets: TKIs treatment potential biomarkers | ||||
| Notes and Dynamics | Other parts of the breast AS mutation rate is AS high AS 73%, 5% to 18%, the mutation is associated with high protein expression | ||||