Parameter
| Biomarker | RAS family (KRAS/HRAS/NRAS) | Full name | Kirsten rat sarcoma viral oncogene homolog / Harvey rat sarcoma viral oncogene homolog / Neuroblastoma RAS viral oncogene homolog | Molecular Type | Nucleic acids (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 21 kDa | Core Functional Dimensions | Therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | All cells (MAPK pathway) | Test Sample / Technology Platform | Organization (NGS, WES, WGS) | ||
| Pathobiological Mechanisms | Activating mutations drive MAPK/ERK pathway, promote cell proliferation and malignant transformation | ||||
| Clinical Availability Status | Study validation: Subtype-specific distribution | ||||
| Notes and Dynamics | The mutation frequency was 14% (0%-53%), which cooperated with BRAF mutation to regulate tumor progression | ||||