Parameter
| Biomarker | TEK::GAB2 gene fusion | Full name | TEK receptor tyrosine kinase::GRB2-associated binding protein 2 gene fusion | Molecular Type | Nucleic acid (RNA/DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 150-200 kDa | Core Functional Dimensions | Diagnostic and therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Vascular endothelial cells, tumor cells | Test Sample / Technology Platform | Tissue (RNA sequencing, RT-PCR, Sanger sequencing) | ||
| Pathobiological Mechanisms | Fusion protein activated PI3K/Akt/mTOR pathway, promotes endothelial cell malignant proliferation | ||||
| Clinical Availability Status | Cutting-edge research: new drive fusion gene | ||||
| Notes and Dynamics | Pediatric pelvic soft tissue was first discovered in the AS, provide new targets for targeted therapy | ||||