Parameter
| Biomarker | NOTCH1::ROS1 fusion gene | Full name | Notch receptor 1::ROS proto-oncogene 1, receptor tyrosine kinase gene fusion | Molecular Type | Nucleic acid (RNA/DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 250-300 kDa | Core Functional Dimensions | Therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Tumor cells (vascular endothelial origin) | Test Sample / Technology Platform | Organization (NGS, RNA sequencing) | ||
| Pathobiological Mechanisms | Fusion protein activated downstream signaling pathways, drive tumorigenesis | ||||
| Clinical Availability Status | Cutting-edge research: radiation related AS found in children | ||||
| Notes and Dynamics | Provide evidence for ROS1 inhibitor therapy | ||||