Parameter
| Biomarker | VEGFR1 / VEGFR2 / VEGFR3 | Full name | Vascular endothelial growth factor receptor 1 / 2 / 3 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | VEGFR1:180 kDa; VEGFR2:150 kDa; VEGFR3:195 kDa | Core Functional Dimensions | Therapeutic targets, prognosis | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Vascular/lymphatic endothelial cells, tumor cells | Test Sample / Technology Platform | Organization (IHC) | ||
| Pathobiological Mechanisms | Combined with VEGF ligand, activate the downstream PI3K/Akt/mTOR and MAPK pathways | ||||
| Clinical Availability Status | Clinical validation/therapeutic targets: TKIs main targets | ||||
| Notes and Dynamics | Expression rate was 78%, 84%, 84% respectively, VEGFR2 lower expression is associated with poor prognosis | ||||