Parameter
| Biomarker | TIE1 / TIE2 (TEK) | Full name | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / TEK receptor tyrosine kinase | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | TIE1:125 kDa; TIE2:125 kDa | Core Functional Dimensions | Targets for Treatment | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Vascular endothelial cells, tumor cells | Test Sample / Technology Platform | Organization (IHC) | ||
| Pathobiological Mechanisms | The specific receptors of endothelial cells, activate the PI3K/Akt/mTOR pathway, steady state regulation of blood vessels | ||||
| Clinical Availability Status | Validation: TIE2 inhibitors in development | ||||
| Notes and Dynamics | The expression rate of TIE2 is 98%, which is the core target of ANGPT-TIE pathway | ||||