Parameter
| Biomarker | p-AKT / p-S6K / p-4EBP1 | Full name | Phosphorylated AKT / Phosphorylated S6 kinase / Phosphorylated 4E-binding protein 1 | Molecular Type | protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | p-AKT:60 kDa; p-S6K:70 kDa; p-4EBP1:15 kDa | Core Functional Dimensions | Therapeutic targets | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Tumor cells | Test Sample / Technology Platform | Tissue (IHC) | ||
| Pathobiological Mechanisms | PI3K/Akt/mTOR pathway activation markers, the regulation of protein synthesis and cell growth | ||||
| Clinical Availability Status | The validation: pathway inhibitors in clinical trials | ||||
| Notes and Dynamics | P-AKT expression rate is 85%, p-4EBP1 expression rate is 88%, the pathway activation is associated with poor prognosis | ||||