Parameter
| Biomarker | SASP factors (IL-6, IL-8, MMP3) | Full name | Senescence-associated secretory phenotype factors (Interleukin-6, Interleukin-8, Matrix metalloproteinase 3) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | IL-6:21 kDa; IL-8:8 kDa; MMP3:54 kDa | Core Functional Dimensions | Prognosis, Monitoring | |
| Disease | Angiosarcoma | Disease Subtypes | / | ||
| Organ | Senescent cells, tumor microenvironment | Test Sample / Technology Platform | Serum (ELISA, SIMOA) | ||
| Pathobiological Mechanisms | Secreted by senescent cells, which promote inflammation and tumor progression | ||||
| Clinical Availability Status | Study validation: indicators for monitoring disease progression | ||||
| Notes and Dynamics | Synergized with PAI-1 to regulate the tumor microenvironment, the serum levels of non-responders were significantly increased | ||||