Parameter
| Biomarker | Fusobacterium nucleatum (Fn) | Full name | Fusobacterium nucleatum | Molecular Type | Bacteria |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and treatment resistance | ||
| Disease | Diagnosis, prognosis, and treatment resistance Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/stool/blood (qPCR, NGS, ELISA) | ||
| Pathobiological Mechanisms | FadA binds E-cadherin to activate the β-catenin signaling pathway, Fap2 binds TIGIT to inhibit NK/T cell function, produce succinate to inhibit the cGAS-STING pathway, and promote immunosuppression, EMT, and chemotherapy resistance | ||||
| Clinical Availability Status | Research validation/early clinical: Stool and tumor tissue tests have been widely used in research; Blood tests are being validated on a large scale | ||||
| Notes and Dynamics | F. animalis C2 clade is the core biomarker of CRC, and its subtype F. animalis C2 clade is the most associated with CRC. The multi-dimensional stool panel has great potential for clinical transformation | ||||