Parameter
| Biomarker | Colistin damage characteristics can be used as a molecular fingerprint for early diagnosis of CRC, and combined detection with Fn can improve the diagnostic accuracy Enterotoxigenic Bacteroides fragilis (ETBF) | Full name | Enterotoxigenic Bacteroides fragilis | Molecular Type | Bacteria |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, Prognosis | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/feces (qPCR, ELISA) | ||
| Pathobiological Mechanisms | The production of BFT toxin clefts E-cadherin to release β-catenin, activates the expression of c-Myc, and inhibits miR-149-3p to promote inflammation and proliferation | ||||
| Clinical Availability Status | Research validation: It has been confirmed to be associated with CRC progression in clinical samples and is in the preclinical transformation stage | ||||
| Notes and Dynamics | Downregulation of FXR can promote its colonization, and targeting FXR or ETBF is expected to become a preventive and therapeutic strategy for CRC | ||||