Parameter
| Biomarker | Anaerobic Peptostreptococcus (P. anaerobius) | Full name | Peptostreptococcus anaerobius | Molecular Type | Bacteria |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, treatment resistance | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/stool (qPCR, metagenomic sequencing) | ||
| Pathobiological Mechanisms | PCWBR2 binds integrin α2β1 to activate PI3K-Akt-NF-κB pathway, generate IDA to inhibit ferroptosis, recruit MDSCs and lead to immunotherapy resistance | ||||
| Clinical Availability Status | Research validation: its cancer-promoting effect in CRC has been identified and it is in the early clinical research stage | ||||
| Notes and Dynamics | It is a key mediator of chemotherapy and immunotherapy resistance in CRC, and targeting its metabolites IDA or adhesin proteins has therapeutic potential | ||||