Parameter
| Biomarker | miRNA-155 | Full name | microRNA-155 | Molecular Type | microrna |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and treatment resistance | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood/stool (qRT-PCR, RNA sequencing) | ||
| Pathobiological Mechanisms | Targeted SOCS1, FOXO3a gene, the activation of PI3K/AKT, the nf-kappa B pathway, promote cell proliferation, EMT and chemotherapy drug resistance; At the same time, it can affect the tumor microenvironment by regulating the function of immune cells | ||||
| Clinical Availability Status | Clinical research phase: its diagnostic and prognostic value has been verified in multi-center clinical samples, and it has not entered routine clinical practice | ||||
| Notes and Dynamics | antisense oligonucleotides targeting miRNA-155 have been shown to be effective in preclinical studies, which are both tumor promoters and potential therapeutic targets | ||||