Parameter
| Biomarker | CXCL1 | Full name | Chemokine (C-X-C motif) ligand 1 | Molecular Type | Chemokines |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and immune regulation | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood (ELISA, qRT-PCR) | ||
| Pathobiological Mechanisms | Binding CXCR2 recruits neutrophils and MDSCs, inhibits CD8+ T cell function, promotes angiogenesis and EMT, and is associated with liver metastasis of CRC | ||||
| Clinical Availability Status | Study validation/Early clinical: Blood tests show prognostic value and are in the clinical research stage | ||||
| Notes and Dynamics | Its expression is regulated by mutant p53 and is highly expressed in p53-mutant CRC. Targeting the CXCL1/CXCR2 axis can enhance the effect of immunotherapy | ||||