Parameter
| Biomarker | CXCL8 (IL-8) | Full name | Interleukin-8 / Chemokine (C-X-C motif) ligand 8 | Molecular Type | Chemokines |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and treatment resistance | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood/stool (ELISA, qRT-PCR) | ||
| Pathobiological Mechanisms | Combining CXCR1 / CXCR2 recruit neutrophils, activated PI3K/AKT pathway, promoting tumor angiogenesis, proliferation, invasion, and associated with CRC immunotherapy drug resistance | ||||
| Clinical Availability Status | Clinical research phase: Serum levels are associated with CRC stage and metastasis, which is in the stage of therapeutic target validation | ||||
| Notes and Dynamics | Serum CXCL8 level can be used as potential markers of CRC prognosis and treatment response monitoring, CXCR2 inhibitors with immunotherapy shows synergistic effect | ||||