Parameter
| Biomarker | CXCL12 | Full name | Chemokine (C-X-C motif) ligand 12 (Stromal cell-derived factor 1) | Molecular Type | Chemokines |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and prediction of metastasis | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood (ELISA, qRT-PCR) | ||
| Pathobiological Mechanisms | Combined with CXCR4 / CXCR7 PI3K/AKT activation, MAPK pathway, promote tumor cell migration, invasion and distant metastasis, transfer recess in participation | ||||
| Clinical Availability Status | Research validation: Its key role in CRC metastasis has been confirmed and it is in the stage of clinical transformation research | ||||
| Notes and Dynamics | CXCL12-CXCR4/CXCR7 axis is an important pathway mediating liver metastasis of CRC, and CXCR4 antagonists have entered clinical trials for CRC | ||||