Parameter
| Biomarker | CXCL16 | Full name | Chemokine (C-X-C motif) ligand 16 | Molecular Type | Chemokines |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and immune regulation | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood (ELISA, qRT-PCR) | ||
| Pathobiological Mechanisms | The membrane-bound form mediates cell adhesion, and the soluble form recruits CXCR6+ T cells to promote angiogenesis in BRAF-mutant CRC | ||||
| Clinical Availability Status | Study validation: it is associated with poor prognosis of CRC with BRAF V600E mutation, which is in the stage of clinical association study | ||||
| Notes and Dynamics | High expression of CXCR6 is associated with the benefit of immunotherapy in CRC patients, and CXCL16-CXCR6 axis can be used as a predictive target for the efficacy of immunotherapy | ||||