Parameter
| Biomarker | S100A4 | Full name | S100 calcium-binding protein A4 | Molecular Type | Calcium-binding protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and prediction of metastasis | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood/feces (ELISA, IHC, qRT-PCR) | ||
| Pathobiological Mechanisms | Activation of NF-κB and PI3K/AKT/mTOR pathways can promote cell motility, invasion and angiogenesis, and participate in the EMT process | ||||
| Clinical Availability Status | Clinical research phase: Tissue and blood tests have confirmed their prognostic value, and targeted inhibitors enter pre-clinical development | ||||
| Notes and Dynamics | It is a key marker of CRC metastasis, and its inhibitor nicotinamide has shown anti-metastatic effect in phase II clinical trials | ||||