Parameter
| Biomarker | S100A8/S100A9 (calprotectin) | Full name | S100 calcium-binding protein A8/A9 heterodimer (Calprotectin) | Molecular Type | Calcium binding protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, immunomodulation | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Stool/blood/tumor tissue (ELISA, IHC, qRT-PCR) | ||
| Pathobiological Mechanisms | The formation of heterodimers binds TLR4/RAGE, activates the NF-κB and MAPK pathways, recruits neutrophils and MDSCs, and promotes inflammation and immunosuppression | ||||
| Clinical Availability Status | Clinically available (inflammation monitoring) : Fecal calprotectin testing has been used as an auxiliary diagnosis for CRC screening; Its tumor-specific application is in the stage of clinical research | ||||
| Notes and Dynamics | It is a core marker of the inflammatory microenvironment of CRC, which is closely related to IBD-related CRC, and can be used as a monitoring indicator of disease activity and treatment response | ||||