Parameter
| Biomarker | S100A10 | Full name | S100 calcium-binding protein A10 (Annexin II ligand, Calpactin I light chain) | Molecular Type | Calcium-binding protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, treatment resistance | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood (IHC, qRT-PCR) | ||
| Pathobiological Mechanisms | It interacts with ANXA2 to mediate oxaliplatin resistance and promote cell invasion and metastasis | ||||
| Clinical Availability Status | Research validation: its role in CRC chemoresistance has been clearly defined, and it is in the stage of preclinical therapeutic target research | ||||
| Notes and Dynamics | It is highly specific for oxaliplatin resistance and can be used as a reference marker for chemotherapy regimen selection. Targeting its interaction with ANXA2 can reverse drug resistance | ||||