Parameter
| Biomarker | S100P | Full name | S100 calcium-binding protein P | Molecular Type | Calcium binding protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and treatment resistance | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Tumor tissue/blood/stool (ELISA, IHC, qRT-PCR) | ||
| Pathobiological Mechanisms | Combined with RAGE to activate downstream signaling pathways, inhibition of p53 function, promote the cell proliferation and metastasis, associated with recurrence of CRC | ||||
| Clinical Availability Status | Research validation: Multi-center studies have confirmed its prognostic value and it is in the clinical transformation stage | ||||
| Notes and Dynamics | It is highly expressed in both primary CRC and metastatic lesions, which can be used as a potential marker for recurrence risk assessment. Its inhibitor, cromoline, has shown efficacy in pre-clinical studies | ||||