Parameter
| Biomarker | Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) | Full name | UDP-glucuronosyltransferase 1-1 | Molecular Type | Proteins |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Treatment prediction | ||
| Disease | Colorectal Cancer (CRC) | Disease Subtypes | / | ||
| Organ | Colorectal | Test Sample / Technology Platform | Blood (genotyping, enzyme activity testing) | ||
| Pathobiological Mechanisms | It is involved in irinotecan metabolism, and its genetic polymorphisms affect drug toxicity and efficacy | ||||
| Clinical Availability Status | Clinical can be used as a guide (treatment), have been used to CRC, stand for kang chemotherapy dose adjustment basis | ||||
| Notes and Dynamics | It is the first biomarker for individualized dose adjustment of CRC chemotherapy, which can effectively reduce the risk of serious adverse reactions | ||||