Parameter
| Biomarker | SECTM1 | Full name | Secreted and transmembrane protein 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis, immune regulation | ||
| Disease | Esophageal Carcinoma | Disease Subtypes | / | ||
| Organ | Esophagus | Test Sample / Technology Platform | Tissue/cell (qPCR, Western blotting, IHC) | ||
| Pathobiological Mechanisms | Promote the proliferation, migration and invasion of ESCC cells; By inducing the expression of chemokine CCL5, it can promote the polarization of macrophages to M2 phenotype and enhance the tumor immunosuppressive microenvironment | ||||
| Clinical Availability Status | Clinical research phase: A prognostic model based on SECTM1 has been constructed to verify its correlation with the poor prognosis of patients | ||||
| Notes and Dynamics | It is a key immune-related tumor promoting factor of ESCC, which provides new ideas for immunotherapy combined targeting strategy | ||||