Parameter
| Biomarker | HPSE | Full name | Heparanase | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis, therapeutic targets | ||
| Disease | Esophageal Carcinoma | Disease Subtypes | / | ||
| Organ | Esophagus | Test Sample / Technology Platform | Tissue/plasma (IHC, qPCR, MR Analysis) | ||
| Pathobiological Mechanisms | As a key enzyme, it degrades extracellular matrix and participates in tumor invasion, metastasis and angiogenesis. The low expression associated with adverse outcomes in patients with ESCC, through the Wnt/beta - catenin pathway regulating tumor progression | ||||
| Clinical Availability Status | Clinical research phase: The causal relationship with ESCC was verified by Mendelian randomization analysis, and the existing drugs (heparin, dalteparin) could be targeted | ||||
| Notes and Dynamics | It is a therapeutic target with great translational value, and further clinical verification of targeting efficacy is needed | ||||