Parameter
| Biomarker | CA72-4 (carbohydrate antigen 72-4) | Full name | Carbohydrate antigen 72-4 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and monitoring | ||
| Disease | Gastric Cancer | Disease Subtypes | / | ||
| Organ | Stomach | Test Sample / Technology Platform | Serum (ELISA, chemiluminescence immunoassay), tumor tissue (IHC) | ||
| Pathobiological Mechanisms | Mucin-associated antigens are rarely expressed in normal tissues, but highly expressed in gastric cancer cells due to abnormal gene regulation. Mucin-associated antigens promote tumor metastasis by enhancing abnormal intercellular adhesion. The specificity of mucin-associated antigens in the diagnosis of gastric cancer (> 90%) is higher than CEA and CA19-9 | ||||
| Clinical Availability Status | Clinical availability (auxiliary diagnosis/prognosis evaluation) : routine clinical tests have low sensitivity (18%-30%) when used alone, and are often used as one of the combined detection combinations | ||||
| Notes and Dynamics | The relative specific markers of gastric cancer have better diagnostic value for gastric adenocarcinoma than for squamous cell carcinoma, and the continuous increase after surgery indicates a high risk of recurrence. The combination of CEA and CA19-9 can increase the diagnostic sensitivity to 60%-70%, which is an important supplementary indicator for the accurate diagnosis of gastric cancer | ||||