Parameter
| Biomarker | hsa_circ_0001789 (circular RNA) | Full name | Circular RNA hsa_circ_0001789 | Molecular Type | Non-coding RNA (circRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and Prognosis | ||
| Disease | Gastric Cancer | Disease Subtypes | / | ||
| Organ | Stomach | Test Sample / Technology Platform | Plasma (qPCR, digital PCR), tumor tissue (qPCR, in situ hybridization) | ||
| Pathobiological Mechanisms | The low expression of hsa_circ_0001789 in gastric cancer tissues and plasma can regulate the downstream FOXO3a pathway by sponge adsorption of miR-182-5p, and inhibit the proliferation and invasion of tumor cells. The low expression is positively correlated with late tumor stage and lymph node metastasis | ||||
| Clinical Availability Status | Basic research: it is in the stage of cell and animal experiments, and clinical samples are less verified | ||||
| Notes and Dynamics | circRNA has high stability (resistance to nuclease degradation) and is an ideal liquid biopsy marker. hsa_circ_0001789 has good stability in plasma. Large-scale clinical studies are needed to verify its diagnostic and prognostic value in the future | ||||