Parameter
| Biomarker | lncRNA HOTAIR (long non-coding RNA HOTAIR) | Full name | Long non-coding RNA HOX transcript antisense RNA | Molecular Type | Non-coding RNA (lncRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Prognosis and Prediction | ||
| Disease | Gastric Cancer | Disease Subtypes | / | ||
| Organ | Stomach | Test Sample / Technology Platform | Tumor tissue (qPCR, RNA in situ hybridization), serum (qPCR) | ||
| Pathobiological Mechanisms | Carcinogenic lncRNA, HOTAIR is highly expressed in gastric cancer tissues, which can inhibit the expression of tumor suppressor genes (such as p21) by recruiting PRC2 complex, promote tumor proliferation, invasion and chemotherapy resistance (such as resistance to cisplatin), and patients with high expression have poor response to chemotherapy | ||||
| Clinical Availability Status | Basic research/early clinical: Small sample clinical studies have shown its prognostic value and positive correlation with the risk of gastric cancer recurrence, which needs large-scale validation | ||||
| Notes and Dynamics | Representative markers in the field of lncRNA can be used as predictors of the prognosis and chemotherapy resistance of gastric cancer. siRNA or antisense oligonucleotide (ASO) targeting HOTAIR can reverse chemotherapy resistance, which is a potential strategy for combined chemotherapy | ||||