Parameter
| Biomarker | APC (Adenomatous polyposis coli) | Full name | Adenomatous polyposis coli protein | Molecular Type | Protein/nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and prognosis | ||
| Disease | Gastric Cancer | Disease Subtypes | / | ||
| Organ | Stomach | Test Sample / Technology Platform | Tumor tissues (IHC, methylation-PCR, NGS) | ||
| Pathobiological Mechanisms | APC gene methylation or mutation is common in intestinal type gastric cancer, which can not inhibit β-catenin nuclear translocation, activate Wnt pathway, promote abnormal cell proliferation, intestinal metaplasia and tumorigenesis, and is positively correlated with the progression of gastric precancerous lesions | ||||
| Clinical Availability Status | Basic research/early clinical: used for monitoring the progression of gastric precancerous lesions (such as adenoma), auxiliary diagnosis of intestinal type gastric cancer, needs clinical verification | ||||
| Notes and Dynamics | As a key marker for the occurrence and development of intestinal type gastric cancer, APC methylation detection can be used for the screening of high-risk population of intestinal type gastric cancer, and combined detection with serum PG can improve the detection rate of gastric precancerous lesions, which is an important indicator for the primary prevention and early intervention of intestinal type gastric cancer | ||||