Parameter
| Biomarker | E-cadherin (epithelial calcium adhesion protein) | Full name | Epithelial cadherin (CDH1) | Molecular Type | Protein/nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and prognosis | ||
| Disease | Gastric Cancer | Disease Subtypes | / | ||
| Organ | Stomach | Test Sample / Technology Platform | Tumor tissues (IHC, NGS) | ||
| Pathobiological Mechanisms | CDH1 gene is a cell adhesion molecule encoded by CDH1 gene. The mutation or methylation of CDH1 gene is common in diffuse type of gastric cancer, which leads to the loss of E-cadherin expression and the decrease of intercellular adhesion, promotes the diffuse invasion of tumor cells and peritoneal metastasis, and is related to the typical pathological characteristics of diffuse type of gastric cancer | ||||
| Clinical Availability Status | Clinical usefulness (subtype diagnosis) : for the diagnosis and classification of diffuse gastric cancer (especially hereditary diffuse gastric cancer), CDH1 mutation carriers should be screened regularly | ||||
| Notes and Dynamics | CDH1 germline mutation, a characteristic marker of diffuse gastric cancer, is the cause of hereditary diffuse gastric cancer (HDGC). Prophylactic gastrectomy is recommended for carriers. Patients with E-cadherin deletion have a high risk of peritoneal metastasis, and surveillance for peritoneal metastasis should be strengthened | ||||