Parameter
| Biomarker | GPC1 | Full name | Glypican-1 | Molecular Type | Proteins |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Early diagnosis and prognosis evaluation | ||
| Disease | Pancreatic Cancer | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Serum (exosome isolation + immunoassay, flow cytometry) | ||
| Pathobiological Mechanisms | Membrane anchor proteins, expressed in PDAC cells and tissues, participate in tumor cell proliferation, invasion and angiogenesis, outside the secrete body form can reflect the tumor biological behavior | ||||
| Clinical Availability Status | Clinical research phase: outside secrete GPC1 detection sensitivity and specificity of close to 100%, but still needs to be large scale validation | ||||
| Notes and Dynamics | Controversial, as a better prognostic marker instead of diagnostic markers, not organization specificity protein, need clotting factor cleavage interference | ||||