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1118

Parameter
Biomarker GPC1⁺ exosomes Full name Glypican-1 positive exosomes Molecular Type Protein (secrete related)
Molecular Formula Molecular Weight Core Functional Dimensions Early diagnosis and prognosis evaluation
Disease Pancreatic Cancer Disease Subtypes /
Organ Pancreas Test Sample / Technology Platform Serum (outside secrete separation flow cytometry) +
Pathobiological Mechanisms Outside GPC1 body surface protein secretion, and by the PDAC cells secrete, participate in tumor microenvironment niche form before regulation and distant metastasis
Clinical Availability Status Clinical research phase: diagnostic sensitivity and specificity are close to 100%, which has been verified in large-scale samples
Notes and Dynamics Can distinguish between PDAC and chronic pancreatitis and healthy people, is independent of disease specific prognostic markers, and prognostic value is better than that of CA19-9

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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