Parameter
| Biomarker | LYVE1 + REG1A + TFF1 joint (panel) | Full name | Lymphatic vessel endothelial hyaluronan receptor 1 + Regenerating islet-derived 1A + Trefoil factor 1 | Molecular Type | Protein combinations |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Early diagnosis | ||
| Disease | Pancreatic Cancer | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Urine (immunoassay, mass spectrometry) | ||
| Pathobiological Mechanisms | LYVE1 participate in lymph angiogenesis, REG1A regulate pancreatic secretion, TFF1 participate in mucosal protection and cell proliferation, combined can reflect the PDAC early molecular changes | ||||
| Clinical Availability Status | Clinical research phase: a urine sample is convenient, suitable for mass screening | ||||
| Notes and Dynamics | It has been verified by case-control studies and has a high level of AUC for the diagnosis of early PDAC, with obvious advantages of non-invasiveness | ||||