Parameter
| Biomarker | tRF3-Thr-AGT | Full name | tRNA-derived fragment 3-Thr-AGT | Molecular Type | Trna-derived small RNA (tsRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and Prognosis | ||
| Disease | Acute pancreatitis (AP) | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Serum (RNA sequencing, qRT-PCR) | ||
| Pathobiological Mechanisms | ZBP1 inhibits NLRP3-mediated pyroptosis and inflammation by binding to its 3'-UTR region, and its down-regulation will aggravate AP inflammatory injury | ||||
| Clinical Availability Status | Cutting-edge research: already validation functions in the cell and animal models, clinical samples showed abnormal expression | ||||
| Notes and Dynamics | It can affect the progression of AP by regulating pancreatic acinar cell pyroptosis, which is a potential non-invasive diagnostic marker and therapeutic target | ||||