Throughout the lifespan, environmental exposures, lifestyle, infections, chronic inflammation, metabolic remodeling, and aging continuously influence the human body. Changes in barrier integrity, circadian rhythm, immune balance, metabolic flexibility, and neurocognitive function collectively shape the dynamic transition from health to subhealth and disease. Because many chronic diseases develop gradually and may remain clinically silent for years, biomarkers provide an important means of identifying early biological changes, assessing risk, monitoring disease progression, and supporting preventive health management. This website provides a systematic resource for exploring biomarkers across the health–disease continuum. It integrates biomarkers from multiple modalities, including nucleic acids and epigenetic modifications, proteins and cytokines, metabolites, microbiota, exosomes, imaging features, electrophysiological signals, clinical functional indicators, and other emerging digital and molecular measures. The database covers nine major physiological systems, including the neurological, cardiovascular, digestive, respiratory, endocrine and metabolic, immune, urinary, reproductive, and musculoskeletal systems, involving 25 key organs and tissues. It further organizes biomarker information for 65 representative diseases, highlighting their potential roles in early warning, disease classification, risk stratification, functional assessment, treatment monitoring, and prognosis evaluation. In addition to disease- and organ-based biomarkers, the website also incorporates the nine traditional Chinese medicine (TCM) constitution types: Balanced Constitution, Qi-deficiency Constitution, Yang-deficiency Constitution, Yin-deficiency Constitution, Phlegm-dampness Constitution, Dampness-heat Constitution, Blood-stasis Constitution, Qi-stagnation Constitution, and Special Constitution. For each constitution, available molecular, metabolic, immune, microbial, physiological, and other objective biomarkers are systematically collected and organized. By integrating physiological systems, organs, diseases, TCM constitutions, and multimodal biomarkers within a unified framework, the website provides a multidimensional view of human health. It enables users to explore shared biomarkers across diseases, identify links between constitutional susceptibility and comorbidity patterns, and examine how biomarkers change across different stages of health and disease. In this way, the platform connects modern biomarker-based risk prediction with the TCM concept of “preventive treatment of disease, supporting research in early detection, precision prevention, and lifelong health management.